Page 32 - HPIC-Magazine (Feb-2021)

An ancestral

Special Article

Table 1: Neutralizing agents versus alcohol level of tap water, chelating agent at
a level of about 0.05-0.10% (w/w%) fermented remedy
Neutralizer (INCI Name) Maximum Alcohol Neutralization Ratio* is recommended).
Level (w/w) (Neutralizer/
Acrypol® 956) Mix water-polymer mixture until a
lump-free dispersion is obtained.
Sodium Hydroxide (20%) 20% 2.3/1
Slowly add the alcohol with agita-
Potassium Hydroxide (20%) 30% 2.7/1 tion and mix until homogeneous.
Triethanolamine (99%) 62% 1/1 Add emollients if desired (The
water-soluble emollients can be
Aminomethyl Propanol 70% 0.9/1
added directly to the water and
Diisopropanolamine 75% 1.5/1 polymeric dispersion or just before
neutralization. The emollients are
Triisopropanolamine 80% 1.5/1
used from 0.3-0.5 wt. % addition.
Ratio values indicated are for hydro-alcoholic mucilages The use of emollients may impact
the final product clarity depend-
Table 2: Formulation of hydro-alcoholic hand sanitizing gel ing on the solubility profile of
Ingredient Weight Function that particular emollient. Other
emollients, such as isopropyl myri-
Demineralized water 28.21 Vehicle
state, may need to be added to
Acrypol 956 0.3 Thickener the alcohol).
Ethanol 70.00 Solvent Add the appropriate neutralizing
agent with gentle agitation and
Glycerin 1.00 Humectant
mix until smooth. The choice of
Acrymine A-100 (AMP)* 0.29 Neutralizer neutralizer depends on the al-
cohol loading percentage in the
Water soluble colour 0.2 Colorant
hydro-alcoholic formula.
Fragrance Q.S. Perfume For attaining maximum clarity
*Use quantity for product pH up to 7.2-7.5 appropriate pH is to be obtained
for hand sanitizing gel. (For Acry-
Water, Rheology Modifier, Neutra- pol® 956 polymer will precipitate pol® 956 polymer the optimum
lizer, Emollients. The effectiveness of out because it is no longer soluble in pH is around 7.0-7.5. Evaluating
the hand sanitizing gel depends on either the water or ethanol. various pH levels and neutralizing
the percentage of alcohol loading in amines combination is a key to
the formula and the use of Acrypol® Table 3: Physical properties of determine the best clarity for spe-
956 will create high transparency hydro-alcoholic hand sanitizing gel cific formulation).
gels to prevent dripping of the gel Property Value Use water soluble dyes. Dyes
®
content and will maximize contact supplied as powders should be Crodarom Cider Vinegar EC
of alcohol and skin during cleaning. Viscosity 12,000-14,000 cps made into dilute (1-3 wt. %) solu-
The chart aids in selection of Acry- (Brookfield tions and added at the end of the
pol® 956 based on the key desirable at 20 rpm) formulation. The oil soluble fra-
properties of Hand sanitizing gels. Appearance Transparent grances should be post added at An old grandmothers’ remedy for health and well-being
low levels.
The selection of right neutralizer pH 7.2-7.5 A composition higher than that of the other vinegars
is essential for obtaining reliable re- COREL PHARMA CHEM
sults in case of hydro-alcoholic gel Formulation Guidelines Corel House An astringent ingredient to treat oily skin and ‘maskne’ troubles
preparations whose neutralization Disperse the polymer into the Opp. Bhagwat Petrol Pump

is more complicated due to amine water (Use deionized water. Acry- Gota, S.G. Highway, An elixir to rebalance the scalp and improve hair shine
solubility limits in high alcohol and pol® 956 polymers are sensitive Ahmedabad 382481, Gujarat.
low water content of hydro-alcoholic to hard water ions which nega- Tel: +91-8000880011/22/33
preparations. With wrong selection tively impacts final product clarity E-Mail: corel@corelpharmachem.com
Website: www.corelpharmachem.com
of neutralizer, the salt of the Acry- and viscosity therefore, in case Croda India Company Private Ltd
Smart science to improve lives ™ Tel +91 22 3094 8511
32 Home, Personal & Institutional Care India February 2021 PC-india@croda.com